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Korean Journal of Head & Neck Oncology 2010;26(1):14-18.
Published online May 30, 2010.
Utility of FDG PET-CT Scans on Nodal Staging of Squamous Cell Carcinoma in the Oral Cavity and Oropharynx
Young-Hoon Joo;Dong-Il Sun;Jun-Ook Park;Ie-Ryung Yoo;Min-Sik Kim
구강 및 구인두 편평상피암종의 림프절 전이에 대한 PET-CT 영상의 유용성
주영훈;선동일;박준욱;유이령;김민식
Abstract
Objectives :We evaluated the use of FDG PET/CT for the identification of cervical nodal metastases of SCC of the oral cavity and oropharynx with histological correlation. Material and Methods :We reviewed 46 medical records, from January 2004 to July 2007, of patients who underwent FDG PET/CT and CT/MRI for SCC of the oral cavity and oropharynx before surgery. We recorded the lymph node metastases according to the neck level affected and the system used for the imaging-based nodal classification. Results :The FDG PET/ CT had a sensitivity of 75.6% and a specificity of 96.7%;it had a higher sensitivity than the CT/MRI for identi-fication of cervical metastases on the side of the neck(26/28 vs. 20/28, p=0.031) and at each of the cervical levels(34/45 vs. 26/45, p=0.008). There was a significant difference in the SUV max between the benign and malignant cervical lymph nodes(3.31±3.23 vs. 4.22±2.57, p=0.028). The receiver-operating-characteristic (ROC) curve analysis for differentiating the benign from the malignant cervical lymph nodes, showed that the area under the curve(AUC) of the FDG PET/CT was 0.775. The cut-off value for the SUV max was 2.23 based on the ROC curve. There was a significant correlation between the SUV max and the size of the cervical lymph nodes(Spearman r=0.353, p=0.048). Conclusion :FDG PET/CT images were more accurate than the CT/MRI images. In addition, the SUV max cut-off values were important for evaluating cervical the cervical nodes in the patients with SCC of the oral cavity and oropharynx.
Key Words: Carcinoma, squamous cell, Mouth, Oropharynx, Lymphatic metastasis, Positron-emission tomography


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