| Clinical Features and the Risk Factors of Distant Metastasis in Locally Advanced Advanced Head and Neck Cancer Patients after Induction Chemotherapy Followed Locoregional Control Therapy |
|
Hye Won Lee;Dong Hoon Baek;Kyung Nam Lee;Eun Jung Cho;Hyo Jeong Kim;Young Mi Seol;Moo Kon Song;Young Jin Choi;Ho Jin Shin;Joo Seop Chung;Goon Jae Cho |
| 유도화학요법 및 국소 치료 후 원격전이를 보인 국소 진행성 두경부암 환자군의 임상 특징 및 위험인자에 관한 연구 |
|
이혜원;백동훈;이경남;조은정;김효정;설영미;송무곤;최영진;신호진;정주섭;조군제 |
|
|
|
|
| Abstract |
|
Backgrounds：Head and neck cancer is one of the most prevalent cancers in the world. It tends to remain lo-calized at the primary site and regional lymph nodes, but if distant metastasis occurs, it has a poor prognosis.
This study was performed to evaluate the prevalence of distant metastasis and to determine the risk factor in local-ly advanced head and neck cancer after induction chemotherapy followed locoregional control therapy. Meth-ods：A retrospective review was performed in 420 patients with locally advanced head and neck cancer who treated with induction chemotherapy followed locoregional control therapy from January 2001 to December 2010.
Among them, 31 patients who had distant metastasis as first relapse within 2 years after termination of therapy were analyzed for clinical features and the risk factors of distant metastasis. Results : The overall incidence of distant metastasis was 7.3%. The bone, lung, and liver were the most frequent metastatic organs. In univariate analysis, nodal stage, nasopharyngeal cancer, laryngeal cancer, G3/G4 neutropenia during induction chemother-apy, and concurrent chemoradiotherapy were the influencing factors for distant metastasis. In multivariate analy-sis, advanced N stage and nasopharynx were the risk factors of distant metastasis, and grade 3/4 neutropenia during induction chemotherapy was considered to decrease distant metastasis. Conclusion：This study sug-gests that the advanced N stage is the risk factor of distant metastasis and Grade 3/4 neutropenia during induction chemotherapy can be beneficial against distant metastasis in locally advanced head and neck cancer patients treat-ed with induction chemotherapy followed locoregional control therapy. |
| Key Words:
Distant metastasis, Head and neck, Neutropenia, Nodal stage |
|
PDF Links
Full text via DOI
Download Citation
