| Treatment Outcomes of Brain metastasis from Papillary Thyroid Cancer |
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Hyeonwoo Bae;Seok-Mo Kim;Soo Young Kim;Ho Jin Chang;Bup-Woo Kim;Yong Sang Lee;Hang-Seok Chang;Cheong Soo Park |
| 갑상선 유두암 뇌전이의 치료 효과 |
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배현우;김석모;김수영;장호진;김법우;이용상;장항석;박정수 |
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| Abstract |
Background/Objectives
Brain metastasis (BM) is a rare form of distant metastasis with papillary thyroid cancer
(PTC). Patients with BM of PTC carry a poor prognosis. The aim of this study was to contribute to the understanding of this disease by analyzing patients with BM of PTC.
Materials & Methods
Between March 2003 and December 2013, the patient database was conducted to identify
thyroid cancer patients treated. Among the 22,758 thyroid cancer patients, 14 (0.06 %) were identified to have
metastasis to the brain during follow-up. The medical records of 14 patients with BM were retrospectively reviewed, focusing on the following: patient characteristics, synchronous or previous distant metastasis, treatments including whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery, and characteristics on radiologic findings, time interval between first diagnosis of primary thyroid cancer and BM and survival after BM.
Results
The mean age at initial diagnosis and BM were 50.9 ± 15.8 years and 61.3 ± 12.7 years. The mean
duration between initial diagnosis and BM was 10.4 ± 7.9 years. Patients were treated with varied combinations
of surgery, SRS and WBRT except 4 patients who had refused treatment. The median overall survival (OS) time
after BM diagnosis was 10 months (range 1 -19). Patients receiving treatmenㅁt (WBRT and/or surgery, SRS) had
a significant longer median OS of 16.5 months in comparison to 3.5 months for those treated without treatment.
(p = 0.005)
Conclusion
Patients who received aggressive treatment had a longer OS than those with only supportive care.
Treatment such as surgery, SRS and WBRT should be considered in patients with BM. |
| Key Words:
Brain metastasis, Thyroid cancer, Surgery, Radiotherapy, Survival |
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