Two Cases of Progressive Transformation of Germinal Centers(PTGC) in Head and Neck Area

Korean Journal of Head & Neck Oncology 2015;31(1):34-38.
Published online May 30, 2015.

Won Gue Han;Tae Min Kim;Hee chul Yoon;Gun hwee Yum;Kyoung Ho Oh;oon Young Kwon

두경부에 발생한 Progressive Transformation of Germinal Centers(PTGC) 환자 2예

한원규;김태민;윤희철;염건휘;오경호;권순영

Abstract

Progressive transformation of germinal centers(PTGC) is a rare benign lymph node enlargement characterized by chronic lymphadenopathy and the presence of germinal centers with fused and expanded mantles within a lymph node that are 3-5 times the size of a typical reactive follicle. Although PTGC is reported in 3.5-10% of chronic lymphadenopathy, head and neck surgeons do not often experience this condition and its clinical implications. Al-thoug PTGC is benign disease, it could not be excluded the association with other malignant lymphoid diseases. Therefore, periodic follow up of PTGC patient could be required. We report two cases at this study ; a 16 years old man who visited out-patient clinic due to palpable mass of right cervical area, several months ago, and a 35 years old man who visited out-patient clinic for evaluating right cervical mass. Both of two patients were diagnosed with PTGC. In this study, we focus on the clinic-pathologic features of this uncommon disease along with other literature reviews.

Key Words: Progressive transformation of germinal centers(PTGC), Nodular lymphocyte predominant Hodgkin’s disease(NLPHD), T cell rich B cell lymphoma, Nodal marginal zone B cell lymphoma, Mantle cell lymphoma, 배중심 진행성변이, T세포 풍부 B세포 림프종