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Korean Journal of Head & Neck Oncology 2008;24(2):162-168.
Published online November 30, 2008.
Treatment Outcome after Induction Chemotherapy Followed by Radiation Therapy in Locally Advanced Hypopharyngeal Cancer
Si Yeol Song;Sung Bae Kim;Sang Yoon Kim;Soon Yuhl Nam;Eun Kyung Choi;Jong Hoon Kim;Seung Do Ahn;Hyoung Uk Je;Sang-Wook Lee
진행된 하인두암에서 유도항암화학요법 후 방사선치료의 결과
송시열;김성배;김상윤;남순열;최은경;김종훈;안승도;제형욱;이상욱
Abstract
Purpose
:To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer
Methods
and Materials :From August 1990 to December 2003, forty patients who were treated with in-duction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range:40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median:70.8Gy).
Results
:Median follow-up time was 39.4 months(range:8-115 months). Treatment failures were ob-served in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients.
Conclusion
:Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.
Key Words: Hypopharyngeal cancer, Induction chemotherapy, Radiation therapy, Larynx preservation


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