| Genomic Alterations in Korean Laryngeal Squamous Cell Carcinoma：Array-Comparative Genomic Hybridization |
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Yoon Hee Cho;Soo-Yeun Park;Dong Wook Lee:김한수;Han Su Kim;Ja Hyun Lee:박혜상;Hae Sang Par;Sung Min Chung |
| 한국인 후두 편평 상피 세포암의 유전체 이상분석：Array 비교 유전체 보합법 |
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조윤희;박수연;이동욱;이자현;정성민 |
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| Abstract |
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Head and neck squamous cell carcinoma(HNSCC) still has poor outcome, and laryngeal cancer is the most frequent subtype of HNSCC. Therefore, there is a need to develop novel treatments to improve the outcome of patients with HNSCC. It is critical to gain further understanding on the molecular and chromosomal alteration of HNSCC to identify novel therapeutic targets but genetic etiology of squamous cell carcinoma of the larynx is so complex that target genes have not yet been clearly identified. Array based CGH(array-CGH) allows investigation of general changes in target oncogenes and tumor suppressor genes, which should, in turn, lead to a better understanding of the cancer process. In this study, We used genomic wide array-CGH in tissue spe-cimens to map genomic alterations found in laryngeal squamous cell carcinomas. As results, gains of MAP2, EPHA3, EVI1, LOC389174, NAALADL2, USP47, CTDP1, MASP1, AHRR, and KCNQ5, with losses of SRRM1L, ANKRD19, FLJ39303, ZNF141, DSCAM, GPR27, PROK2, ARPP-21, and B3GAT1 were observed frequently in laryngeal squamous cell carcinoma tissue specimens. These data about the patterns of genomic alterations could be a basic step for understanding more detailed genetic events in the carcinogenesis and also provide information for diagnosis and treatment in laryngeal squamous cell carcinoma. The high resolution of array-CGH combined with human genome database would give a chance to find out possible target genes which were gained or lost clones. |
| Key Words:
Squamous cell carcinoma, Array-CGH, Genomic alteration, Array-CGH. |
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