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Korean Journal of Head & Neck Oncology 2008;24(1):26-32.
Published online May 30, 2008.
Effect of Induction Chemotherapy Followed by Radiation Therapy of Locally Advanced Hypopharyngeal Carcinoma
Jae-Won Kim;Hee Young Son;Sea Yuong Jeon;Jung Je Park;Seong Ki Ahn,;Ki Mun Kang;Jin Pyeong Kim
국소진행된 하인두암에서 선행 항암화학요법과 방사선치료의 효과
김재원;손희영;전시영;박정제;안성기;강기문;김진평
Abstract
Purpose
:Hypopharyngeal carcinoma is usually diagnosed as an advanced disease after an asymptomatic beginning, and it is related to a high frequency of lymph node metastases. An eventual negative outcome may occur not only because of possible locoregional failures but also for frequent distant metastases. Thus, the efficacy of induction chemotherapy followed by radiation therapy, with regards to the response, survival rate and compli-cations for locally advanced hypopharyngeal carcinoma patients, was examined.
Methods
and Materials :Since July 1998 to February 2001, 18 patients having locally advanced hypopha-ryngeal carcinoma were treated with induction chemotherapy followed by radiation therapy, and the results were retrospectively analyzed. The regimen of the induction chemotherapy was the 5-flurouracil(5-FU, 1,000mg/m 2 daily for 5 consecutive days) and cisplatin(100mg/m 2 on day 1) combination at 3-week intervals for 2 cycles. The total radiation dose for the primary tumor and metastatic lymph nodes was 68.4-72.0Gy(median:70.2Gy)
Results
:The 3-year overall survival rate and disease free survival rate were 31.3% and 22.2%, respectively. In 6 patients(33.3%), preservation of the larynx for over 3 years was possible. After the induction chemotherapy and radiotherapy, a complete response was noted in 14 patients(77.8%), and a partial response in 4 patients (22.2%), with an overall response rate of 100%.
Conclusion
:Induction chemotherapy followed by radiation therapy is an effective treatment and larynx pre-servation rate was 33% in patients with locally advanced hypopharyngeal carcinoma in our report.
Key Words: Hypopharyngeal carcinoma, Chemotherapy, Radiation therapy


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