Immunohistochemical Characteristics of Primary and Recurrent Pleomorphic Adenoma

Korean Journal of Head & Neck Oncology 2005;21(2):146-150.
Published online November 30, 2005.

Myung Whan Suh;J Hun Hah;Kyung Bun Lee;Young Ho Jung;Seong Keun Kwon;Kwang Hyun Kim;Myung Whun Sung

원발성 다형선종과 재발성 다형선종의 면역조직화학적 특성

서명환;하정훈;이경분;정영호;권성근;김광현;성명훈

Abstract

Background and Objectives: When the pleomorphic adenoma(PA) recures, the tumor tends to become a multinodular mass that infiltrates into the normal tissue which is not a common condition for a benign tumor. This manifestation is probably due to the difference in cell biology of the recurrent tumor compared to that of the primary PA. The aim of this study is to assay the immunhistochemical characteristics of the recurrent PA compared to the primary PA and to evaluate whether this property can be used for developing a method that can select the patients who have higher risk to recur. Materials and Methods: Thirteen patients were enrolled in the primary PA group and 15 patients who had a recurrent PA were enrolled in the recurrent PA group. To evaluate the cell biology of the tumor, immunohistochemical stainings of Ki-67, bcl-2 and p53 were performed.
Results
There was no difference in the expression of Ki-67 (p=0.117, p=.208) and p53 (p=.430, p=.328). The extent stained by bcl-2 was significantly larger in the recurrent PA group (p=.033, p=.014). The expression of bcl-2 did not increase while time passed.
Conclusion
The high expression of bcl-2 seems to be a property of the recurrent PA group which can be found even during first operation before recurrence. By this immunhistochemical characteristic, we would be able to sort out the patients who have higher risk to recur.

Key Words: Recurrent pleomorphic adenoma, Immunohistochemistry, bcl-2, Ki-67, p53