The Anti-tumor Effect of Polysaccharide from the Leaves of Panax Ginseng C.A. Meyer(MB40) in a Murine Squamous Cell Carcinoma Model

Korean Journal of Head & Neck Oncology 2009;25(1):3-7.
Published online May 30, 2009.

Eun Jung Joo;Jun Choi;Eun Jae Chung;Seok Jin Hong;Jae Gu Cho;Seung Kuk Baek;Jeong Soo Woo;Kwang Yoon Jung;Soon Young Kwon

편평세포암 동물 모델에서 고려인삼잎-다당체(MB40)의 항암치료효과

주은정;최 준;정은재;홍석진;조재구;백승국;우정수;정광윤;권순영

Abstract

Background and Objectives：Panax ginseng C.A. Meyer is a medical plant that has been widely utilized as a tonic and nutritional agent since ancient times in Korea. Ginseng has anti-metastatic property of cancer and immunomodulating activity. The novel acidic polysaccharide compound(MB40) was isolated from the leaves of Panax ginseng C.A. Meyer. To determine immunomodulating activities of MB40, we evaluate anti-cancer and anti-metastatic effects of MB40 in tumor bearing immune competent mice. Material and Methods：C3H mice were divided into three equal groups(Cisplatin treatment group, MB40treat- ment group, Cisplatin and MB40 treatment group) and were transplanted SCC(Squamous Cell Carcinoma) cells(2×106) to the lateral side of abdomen. From day 4 after transplantation, MB40 was administrated at dose of 10mg/kg, respectively, every other day by intratumoral injection. Cisplatin was systemically administrated at doses of 1mg/kg, respectively, every week by intraperitoneal injection.
Results
：5 days after administration, tumors can be palpated in every mice group. After 13 days of administra-tion, the mice group to which MB40 were administrated exhibited reduction in tumor size respectively, com-pared to cisplatin group. Overall status of mice such as body weight and activity were superior in MB40 group than cisplatin group.
Conclusion
：The result of this study indicates MB40 may have significant therapeutic effect and decreases com-plications induced by systemic chemotheraphy. MB40 may be developed as a novel and potent immunotropics to improve the cell immune system and anti-cancer drug for the treatment of cancer patients in head and neck squamous cell carcinoma.

Key Words: Polysaccharide, Leaves, Panax ginseng, Squamous cell carcinoma