| Metastatic Carcinoma of an Unknown Primary Site Presented to the Neck |
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Tae Yong Kim;Yo Han Joh;Jin Su Kim;Yong Sang Hong;Keun Wook Lee;Tak Yun;Eun Ki Song;Im Il Na;Hyun Chun Shin;Dong Wan Kim;Chae Seo RLee;Myung Whun Sung;Dae Seog Heo;Kwang Hyun Kim;Hong Gyun Wu;Noe Kyeong Kim |
| 경부 림프절 종대로 발현한 원발 부위 불명의 전이암 |
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김태용;조요한;김진수;홍용상;이근욱;윤탁;송은기;나임일;신현춘;김동완;이재서;성명훈;허대석;김광현;우홍균;김노경 |
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| Abstract |
Background: About 3% of all cancer patients suffer from cancer of unknown primary origin. Generally, carcinoma of unknown primary (CUP) carries a grave prognosis, but primary tumor presented to the neck is exception to this. The aims of study are to determine the role of chemotherapy and to find the prognostic factors in unknown primary tumor presented to the neck.
Method and Material: Eighty-four patients were diagnosed with unknown primary tumor presented to the neck between January 1996 and June 2002. Among 84 patients, 43 patients (52%) received chemotherapy, radiation or surgery were performed in 20 patients (23%), 21 patients (25%) had no treatment.
Results
The response rates to chemotherapy were 87.5% in CUP only localized to the neck and 44.0% in CUP systemically involved (p=0.012). A median follow-up duration was 6.4 years and overall median survival time was 9 months. The median overall survival time of patients treated with chemotherapy were 17 months and that of patients who received surgery or radiation were 20 months (p=0.3548). The important prognostic factors were performance status and the number of involved organ.
Conclusion
The prognosis of patients with CUP presented to the neck is more favorable than that of patients with CUP of other localization. The effectiveness of chemotherapy for CUP only localized to the neck was similar to that of surgery or radiation. The important prognostic factors were performance status and the number of involved organ. |
| Key Words:
Unknown primary, Cervical lymph node metastases, Chemotherapy, Combined therapy |
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