| Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester |
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Phil-Sang;Sang Oun Jung;Jin Chul Ahn;Sang Joon Lee;Jun Sik Yoon |
| ALA 및 ALA-Methylester의 투여에 따른 종양조직 및 정상조직에의 분포양상에 대한 연구 |
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정필상;정상운;안진철;이상준;윤준식 |
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| Abstract |
Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region.
Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer).
Results
The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region.
Conclusion
According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection. |
| Key Words:
5-아미놀레불리산, 5-Aminolevulatic acid, Photosensitizers, Tumor specificity |
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